The 25th International Conference on Research in Computational Molecular Biology (RECOMB) 2021, will be held in Padova, Italy, on August 29-September 1, 2021. (See Organizers' message


The RECOMB conference series was founded in 1997 to provide a scientific forum for advances in computational biology and applications in molecular biology and medicine. The conference aims at bridging the computational, mathematical, statistical, and biological sciences, and bringing together researchers, professionals, students and industrial practitioners from all over the world for interaction and exchange of new developments in all areas of bioinformatics and computational biology. The conference will feature keynote talks by leading scientists, presentations of peer- reviewed high-quality research papers, presentations of exciting research developments that were published within the past year and poster sessions on latest research progress.


Papers reporting on original research (both theoretical and experimental) with an algorithmic focus in all areas of computational molecular biology are sought. Topics of interest include, but are not limited to:

Molecular sequence analysis

Sequencing and genotyping technologies

Regulation and epigenomics

Transcriptomics, including single-cell


Population and statistical genetics

Evolutionary, compressive and comparative genomics

Structure and function of non-coding RNAs

Computational proteomics and proteogenomics

Protein structure and function

Biological networks

Computational systems biology

Privacy of biomedical data


Submissions should represent original, previously unpublished work. The Program Committee will rigorously review submitted extended abstracts (approximately 10 pages).  Selected papers will be accepted for presentation at the conference. Accepted abstracts will be published as a proceedings volume in the Lecture Notes in Bioinformatics (LNBI) series from Springer-Verlag, which will be available at the conference.  Authors who prefer not to publish their papers in the LNBI proceedings, must submit a final two-page extended abstract for inclusion in the Springer LNBI proceedings in lieu of the full paper and must submit the full paper to the preprint server or by the deadline of the camera ready version to ensure that the presented paper is accessible.  RECOMB is partnering with Cell Systems and the Journal of Computational Biology. Authors of selected accepted papers will be invited, but not required, to submit an edited journal version for a special issue of Cell Systems (as detailed below).  Authors can alternatively choose to submit extended versions of accepted proceedings papers to the Journal of Computational Biology or to pursue the Parallel Submission option, detailed below, to submit their work to an alternative journal of their choosing in parallel with RECOMB submission.


All papers accepted for oral presentations at RECOMB that are of salient biological interest will be considered for the RECOMB special issue of Cell Systems.  Selected authors will be invited to submit to Cell Systems and, if papers are accepted there, they will be included in the RECOMB special issue. Editors at Cell Systems will actively collaborate with RECOMB authors during a streamlined review process involving the RECOMB reviewers and up to 2 additional biological reviewers. Authors will be notified as to whether their paper is accepted for oral presentation at RECOMB and simultaneously whether they will be invited to submit to Cell Systems for consideration in the RECOMB special issue by December 18, 2020.


If a paper is submitted for oral presentation at RECOMB, the authors can simultaneously submit their full paper to the journal of their choice and elect to have a two-page short paper published in the LNBI proceedings in lieu of a full proceedings paper.  Note that full papers accepted to RECOMB must be submitted to a preprint server by the camera-ready deadline as described above.  Papers accepted for oral presentation that have been accepted to a journal other than Cell Systems or Journal of Computational Biology at the time of the meeting may be moved to the Highlights track at the discretion of the PC Chair.

KEY DATES (all deadlines are for 5:00 PM, Eastern U.S. Time)


  • Paper submission opens: September 7, 2020

  • Paper submission deadline: November 2, 2020 (November 6 for final revisions)

  • Paper acceptance decision: December 18, 2020

  • Final versions of papers due: January 22, 2021

  • Highlights submission opens: December 21, 2020

  • NEW Highlights submission deadline:  June 15, 2021  

  • NEW Highlights acceptance decision: July 15, 2021 


  • Poster submission opens: December 4, 2020

  • NEW Poster submission deadline: June 15, 2021  

  • NEW Poster acceptance decision: July 15, 2021 


  • Travel fellowship application deadline: February 19, 2021

  • Travel fellowship notification: February 26, 2021

  • Early registration deadline: TBD



A manuscript should start with a succinct statement of the problem, the results achieved (including algorithmic contributions), their significance, and a comparison with previous work. This material should be understandable to non-specialists. A technical exposition directed to the specialist should follow. The length, excluding cover page, bibliography, and appendix, should not exceed 10 pages. The manuscript should be easy to read, using at least 11 point font size on U.S. standard 8 1/2 by 11 inch paper with no less than one inch margins all around. If the authors believe that more details are absolutely necessary to substantiate the claims of the paper, they may include a clearly marked appendix, or supplementary data, which might be read at the discretion of the reviewers. An email address for the contact author should be included. Manuscripts that deviate significantly from these guidelines risk rejection without consideration of their merits.



Submission of papers to RECOMB2021 will be through the EasyChair conference system, following the link from the conference web page.

The submission system will be open starting September 7 and ending October 30 (November 4 for final submissions) 2020. For full details, please see the submission instructions at the conference website. The Program Committee, chaired by Jian Peng (University of Illinois at Urbana-Champaign, Urbana), will referee the conference submissions.


Authors will be notified of acceptance or rejection by email on or before December 18, 2020. We request that an author of each accepted paper provides LaTeX files or an MS Word file in the special format for Lecture Notes in Bioinformatics by January 22, 2021.


Authors should consult Springer's authors' guidelines and use their proceedings templates, either for LaTeX or for Word, for the preparation of their papers. Springer encourages authors to include their ORCIDs in their papers. In addition, the corresponding author of each paper, acting on behalf of all of the authors of that paper, must complete and sign a Consent-to-Publish form. The corresponding author signing the copyright form should match the corresponding author marked on the paper. Once the files have been sent to Springer, changes relating to the authorship of the papers cannot be made.


Note that Springer LaTeX templates are now available in Overleaf for authors who wish to use Overleaf in their manuscript preparation.

An author of each accepted paper is expected to attend the conference and present the paper; in the rare case of unexpected circumstances, alternative arrangements, approved by the conference chair, should be made to have the paper presented.

Late Revisions Deadline: November 4, 2020

The motivation behind the "revisions only" deadline is to maximize opportunity for quality submissions, while allowing sufficient time for a thorough review.  We will begin assigning reviewers to papers based on the submission as of October 30 but will allow updates until we make papers available to reviewers on November 4.  As a result, we require the following:

  • A substantively complete and comprehensible manuscript must be received by October 30, for a paper to be considered for review.

  • Revised versions of manuscripts received before November 4 will be accepted if and only if they use the same title as the initial submission and improve their content. They can include revisions of both text and methods and may introduce new results but cannot substantially change the scientific premise or methodology. For example, a manuscript describing a deep learning approach to protein structure prediction cannot be revised to describe a combinatorial optimization algorithm for phylogenetic tree reconstruction. Revisions that do not adhere to these guidelines will not be considered.

  • No revisions will be allowed after November 4, 2020.